Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14

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Serval ID
serval:BIB_38A7057EBC60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14
Journal
Molecular Psychiatry
Author(s)
Etain Bruno, Mathieu F., Rietschel Marcella, Maier Wolfgang, Albus M., McKeon Patrick, Roche S., Kealey C., Blackwood D., Muir W., Bellivier Frank, Henry C., Dina C., Gallina S., Gurling H., Malafosse Alain, Preisig Martin, Ferrero François, Cichon S., Schumacher J., Ohlraun S., Borrmann-Hassenbach M., Propping P., Abou Jamra R., Schulze Thomas G., Marusic Andrej, Dernovsek Z.M., Giros B., Bourgeron T., Lemainque A., Bacq D., Betard C., Charon C., Nöthen M.M., Lathrop M., Leboyer Marion
ISSN
1359-4184
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Number
11
Pages
685-694
Language
english
Notes
SAPHIRID:62833
Abstract
Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify vulnerability genes. Thus, the probability of detecting major disease-causing genes might be increased by focusing on families with early-onset BPAD type I probands. This study was conducted as part of the European Collaborative Study of Early Onset BPAD (France, Germany, Ireland, Scotland, Switzerland, England, Slovenia). We performed a genome-wide search with 384 microsatellite markers using non-parametric linkage analysis in 87 sib-pairs ascertained through an early-onset BPAD type I proband (AAO of 21 years or below). Non-parametric multipoint analysis suggested eight regions of linkage with P-values<0.01 (2p21, 2q14.3, 3p14, 5q33, 7q36, 10q23, 16q23 and 20p12). The 3p14 region showed the most significant linkage (genome-wide P-value estimated over 10 000 simulated replicates of 0.015 [0.01-0.02]). After genome-wide search analysis, we performed additional linkage analyses with increased marker density using markers in four regions suggestive for linkage and having an information contents lower than 75% (3p14, 10q23, 16q23 and 20p12). For these regions, the information content improved by about 10%. In chromosome 3, the non-parametric linkage score increased from 3.51 to 3.83. This study is the first to use early-onset bipolar type I probands in an attempt to increase sample homogeneity. These preliminary findings require confirmation in independent panels of families.
Pubmed
Web of science
Open Access
Yes
Create date
13/03/2008 8:39
Last modification date
20/08/2019 13:28
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