Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.

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State: Public
Version: Final published version
Serval ID
serval:BIB_38333B511444
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.
Journal
Bmc Psychiatry
Author(s)
Lazarczyk M.J., Bhuiyan Z.A., Perrin N., Giannakopoulos P.
ISSN
1471-244X (Electronic)
ISSN-L
1471-244X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
12
Pages
220
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
ABSTRACT:
BACKGROUND: Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel. Although the QT-prolonging drugs are proscribed in the subjects with aLQTS, the individual response to diverse QT-prolonging drugs may vary substantially.
CASE PRESENTATION: We report here a case of aLQTS in response to small doses of risperidone that was confirmed at three independent drug challenges in the absence of other QT-prolonging drugs. On the other hand, the patient did not respond with QT prolongation to some other antipsychotics. In particular, the administration of clozapine, known to be associated with higher QT-prolongation risk than risperidone, had no effect on QT-length. A detailed genetic analysis revealed no mutations or polymorphisms in KCNH2, KCNE1, KCNE2, SCN5A and KCNQ1 genes.
CONCLUSIONS: Our observation suggests that some patients may display a selective aLQTS to a single antipsychotic, without a potassium channel-related genetic substrate. Contrasting with the idea of a common target of the aLQTS-triggerring drugs, our data suggests existence of an alternative target protein, which unlike the KCNH2 would be drug-selective.
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2013 12:09
Last modification date
20/08/2019 14:26
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