Microvascular pathology in late-life depression.

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State: Public
Version: author
Serval ID
serval:BIB_382B0D2FE31D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Microvascular pathology in late-life depression.
Journal
Journal of the Neurological Sciences
Author(s)
Santos M., Xekardaki A., Kövari E., Gold G., Bouras C., Giannakopoulos P.
ISSN
1878-5883 (Electronic)
ISSN-L
0022-510X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
322
Number
1-2
Pages
46-49
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Since the era of Gaupp who introduced the concept of atheroscletic depressive disorder, the concept of late-life depression has been correlated with cerebrovascular comorbidities, microvascular lesions, frontal cortical and subcortical gray and white matter hyperintensities. The predominant neuropsychological deficits concern the domains of planning, organization and abstraction, with executive dysfunction being the predominant finding. MRI studies reveal a higher prevalence of white matter lesions in elderly patients with depression. Molecular mechanisms underlying the disease still remain unclear. Hyperhomocysteinemia has been associated with depression through its toxicity to neurons and blood vessels. Endothelial dysfunction is another possible mechanism referring to the loss of vasodilatation capacity. Inflammatory phenomena, such as increased peripheral leucocytes, elevated CRP and cytokine levels, could play a role in endothelial dysfunction. In this review we will briefly combine findings from neurobiological, epidemiological, structural and post-mortem data. A more complex model in late-life depression combining different modalities could be an elucidating approach to the disease's etiopathogeny in the future.
Pubmed
Web of science
Create date
24/10/2012 10:40
Last modification date
20/08/2019 13:26
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