Immunogenicity of a recombinant Pre-S2-containing hepatitis B vaccine versus plasma-derived vaccine administered as a booster

Details

Serval ID
serval:BIB_3816E88B149D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunogenicity of a recombinant Pre-S2-containing hepatitis B vaccine versus plasma-derived vaccine administered as a booster
Journal
European Journal of Clinical Microbiology and Infectious Diseases
Author(s)
Bucher  B., Francioli  P., Geudelin  B., Fritzell  B., Lavanchy  D., Frei  P. C.
ISSN
0934-9723 (Print)
Publication state
Published
Issued date
03/1994
Volume
13
Number
3
Pages
212-7
Notes
Comparative Study
Journal Article --- Old month value: Mar
Abstract
GenHevac B Pasteur is a recombinant hepatitis B vaccine derived from a mammalian cell line and containing HBs as well as pre-S2 antigens. Its immunogenicity was compared to that of the plasma-derived vaccine Hevac B Pasteur in a population primovaccinated 5.5 years earlier with four injections of the same plasma vaccine. The booster injection with either GenHevac or Hevac was administered to 295 subjects with residual anti-HBs titres below 500 IU/l (group 1: 0-9; group 2: 10-99; group 3: 100-499 IU/l). After four weeks, GenHevac had induced higher anti-HBs responses than Hevac in all groups, particularly among the low responders of group 1. Response to the vaccine occurred earlier with GenHevac. Mean anti-pre-S2 production was moderate in all groups for both vaccines (GenHevac: 60 IU/l; Hevac: 31 IU/l) and was not found in the 32 subjects who produced less than 100 IU/l anti-HBs. The results of the present study indicate that GenHevac is at least as immunogenic as Hevac.
Keywords
Adult Female Hepatitis B/immunology/*prevention & control Hepatitis B Antibodies/*blood Hepatitis B Vaccines/*administration & dosage/immunology Humans Immunization, Secondary Male Middle Aged Time Factors Vaccines, Attenuated/*administration & dosage/immunology Vaccines, Synthetic/*administration & dosage/immunology
Pubmed
Web of science
Create date
25/01/2008 17:07
Last modification date
20/08/2019 13:26
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