Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease.

Details

Serval ID
serval:BIB_38109
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease.
Journal
Stroke
Author(s)
Suter O.C., Sunthorn T., Kraftsik R., Straubel J., Darekar P., Khalili K., Miklossy J.
ISSN
1524-4628
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
33
Number
8
Pages
1986-1992
Language
english
Abstract
BACKGROUND AND PURPOSE: The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed cortical infarcts in AD is lacking. METHODS: Brains of 184 autopsy cases (105 definite AD cases and 79 age-matched controls) were selected and analyzed by histochemical and immunohistochemical techniques. The 3-dimensional reconstruction of the whole cerebrum, with 3-mm spaced serial sections, was performed in 6 AD cases to study the intrahemispheric and interhemispheric distribution of the cortical microinfarcts. RESULTS: A significant association (P=0.001) was found between the occurrence of watershed cortical infarcts and AD (32.4% versus 2.5% in controls). The microinfarcts were restricted to the watershed cortical zones. Congophilic angiopathy was revealed to be an important risk factor. Perturbed hemodynamic factors (eg, decreased blood pressure) may play a role in the genesis of cortical watershed microinfarcts. CONCLUSIONS: In AD, cerebral hypoperfusion induces not only white matter changes but cortical watershed microinfarcts as well, further aggravating the degenerative process and worsening dementia. To prevent the formation of watershed cortical microinfarcts in AD, monitoring blood pressure and treating arterial hypotension are essential.
Keywords
Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Amyloid Angiopathy, Cerebral Cortex, Cerebral Infarction, Cerebrovascular Circulation, Cerebrovascular Disorders, Humans, Immunohistochemistry, Middle Aged
Pubmed
Web of science
Create date
19/11/2007 12:36
Last modification date
20/08/2019 13:26
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