Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses.

Details

Serval ID
serval:BIB_37E0BEBA28B4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Cagno V., Gasbarri M., Medaglia C., Gomes D., Clement S., Stellacci F., Tapparel C.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
17/11/2020
Peer-reviewed
Oui
Volume
64
Number
12
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteoglycan (HSPG)-dependent viruses but only in a reversible way. We have previously shown that gold nanoparticles and β-cyclodextrins coated with mercapto-undecane sulfonic acid (MUS) inhibit HSPG-dependent viruses irreversibly while retaining the low-toxicity profile of most heparin-like compounds. In this work, we show that, in stark contrast to heparin, these compounds also inhibit different strains of influenza virus and vesicular stomatitis virus (VSV), which do not bind HSPG. The antiviral action is virucidal and irreversible for influenza A virus (H1N1), while for VSV, there is a reversible inhibition of viral attachment to the cell. These results further broaden the spectrum of activity of MUS-coated gold nanoparticles and β-cyclodextrins.
Keywords
Antiviral Agents/pharmacology, Gold, Heparitin Sulfate/pharmacology, Influenza A Virus, H1N1 Subtype, Metal Nanoparticles, Viruses, antiviral agents, attachment, influenza, nanoparticle, vesicular stomatitis virus
Pubmed
Web of science
Create date
09/07/2024 10:03
Last modification date
10/07/2024 7:06
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