Prevalence, persistence and clinical correlations of classic and novel antiphospholipid antibodies in systemic lupus erythematosus.

Details

Serval ID
serval:BIB_37D7EB2120E6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence, persistence and clinical correlations of classic and novel antiphospholipid antibodies in systemic lupus erythematosus.
Journal
Rheumatology
Author(s)
Marchetti T., Ribi C., Perneger T., Trendelenburg M., Huynh-Do U., de Moerloose P., Chizzolini C.
ISSN
1462-0332 (Electronic)
ISSN-L
1462-0324
Publication state
Published
Issued date
01/08/2018
Peer-reviewed
Oui
Volume
57
Number
8
Pages
1350-1357
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
aPL are frequently present in SLE. In a well characterized SLE cohort we aimed at investigating the prevalence of aPL and assessing their analytical performance and clinical association by testing criteria specificities including LA, aCL IgG and IgM, anti-β2-glycoprotein 1 (antiβ2GP1) IgG and IgM, as well as the non-criteria aPS-PT IgG and IgM and anti-β2GP1 domain 1 (aD1) IgG.
We included 178 patients satisfying the ACR SLE classification criteria, from whom 283 samples and thrombotic events were collected longitudinally. Each sample was tested for criteria and non-criteria aPL using validated techniques in a single centre.
All assays provided highly reproducible results. Of the samples, 42.5% were positive for at least one criteria assay, 20.5% showed double positivity and 12.6% triple positivity. All criteria and non-criteria specificities persisted over time. Most antibody titres were only moderately correlated; however, strong correlation was observed on one hand between aD1 IgG, antiβ2GP1 IgG and aCL IgG, and on the other between aPS-PT IgG and LA. aD1 IgG titres were extremely elevated in triple-positive samples. aPS-PT IgG by itself, and jointly with LA, was associated with thrombosis, an association mostly driven by venous thrombotic events.
In this SLE cohort, the non-criteria aPL aD1 IgG and aPS-PT IgG performed differently. aD1 IgG was highly enriched in triple-positive samples, and aPS-PT IgG, jointly with LA, was associated with thrombotic events.
Keywords
Adolescent, Adult, Aged, Antibodies, Antiphospholipid/immunology, Antiphospholipid Syndrome/classification, Antiphospholipid Syndrome/ethnology, Antiphospholipid Syndrome/immunology, Child, Female, Follow-Up Studies, Humans, Lupus Erythematosus, Systemic/classification, Lupus Erythematosus, Systemic/epidemiology, Lupus Erythematosus, Systemic/immunology, Male, Middle Aged, Prevalence, Prospective Studies, Switzerland/epidemiology, Thrombosis/epidemiology, Thrombosis/immunology, Time Factors, Young Adult
Pubmed
Web of science
Create date
26/04/2018 19:13
Last modification date
20/08/2019 14:26
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