Paradoxical Psoriasis: An Updated Review of Clinical Features, Pathogenesis, and Treatment Options.
Details
Serval ID
serval:BIB_37D52048BB09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Paradoxical Psoriasis: An Updated Review of Clinical Features, Pathogenesis, and Treatment Options.
Journal
The Journal of investigative dermatology
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Publication Status: aheadofprint
Abstract
The definition of paradoxical psoriasis (PP) encompasses 2 main scenarios, namely, (i) new-onset psoriasis in patients treated for a different disease and (ii) worsening as well as phenotypical change of pre-existing psoriasis. Originally restricted to the appearance of an untoward psoriasiform reaction under TNF inhibitors, the term has gained new meaning, with the progressive observation of psoriasis-like eruptions also with other medications. Although the conceptual framework of PP has expanded, a molecular and clinicotherapeutic classification is still lacking. In addition, a certain degree of confusion surrounds the correct terminology to indicate these eruptions. In this paper, evidence on the epidemiology, clinical features, pathogenesis, and treatment of PP is reviewed, providing a perspective on possible pathogenesis-driven therapeutic approaches.
Keywords
Biologics, Dupilumab, Paradoxical psoriasis, Psoriasiform reaction, TNF inhibitors
Pubmed
Create date
11/07/2024 15:43
Last modification date
12/07/2024 7:04