Paradoxical Psoriasis: An Updated Review of Clinical Features, Pathogenesis, and Treatment Options.

Details

Serval ID
serval:BIB_37D52048BB09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Paradoxical Psoriasis: An Updated Review of Clinical Features, Pathogenesis, and Treatment Options.
Journal
The Journal of investigative dermatology
Author(s)
Maronese C.A., Valenti M., Moltrasio C., Romagnuolo M., Ferrucci S.M., Gilliet M., Costanzo A., Marzano A.V.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
The definition of paradoxical psoriasis (PP) encompasses 2 main scenarios, namely, (i) new-onset psoriasis in patients treated for a different disease and (ii) worsening as well as phenotypical change of pre-existing psoriasis. Originally restricted to the appearance of an untoward psoriasiform reaction under TNF inhibitors, the term has gained new meaning, with the progressive observation of psoriasis-like eruptions also with other medications. Although the conceptual framework of PP has expanded, a molecular and clinicotherapeutic classification is still lacking. In addition, a certain degree of confusion surrounds the correct terminology to indicate these eruptions. In this paper, evidence on the epidemiology, clinical features, pathogenesis, and treatment of PP is reviewed, providing a perspective on possible pathogenesis-driven therapeutic approaches.
Keywords
Biologics, Dupilumab, Paradoxical psoriasis, Psoriasiform reaction, TNF inhibitors
Pubmed
Create date
11/07/2024 15:43
Last modification date
12/07/2024 7:04
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