Comparison between short- and long-term insulin-like growth factor response to recombinant human growth hormone
Details
Serval ID
serval:BIB_37C0AA92EC77
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison between short- and long-term insulin-like growth factor response to recombinant human growth hormone
Journal
Hormone Research
ISSN
0301-0163 (Print)
Publication state
Published
Issued date
1992
Volume
38
Number
5-6
Pages
245-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Eight growth-hormone-deficient children were treated with recombinant human GH (rhGH). Results of the short-term metabolic response to rhGH performed at the start of therapy during a 5-day introduction period and long-term results on growth were analyzed. We could not find any correlation between the effects on the short-term metabolic test and the growth response during long-term therapy, namely between the urea and insulin-like growth factor-I response during the short test and the increase in growth velocity. The short-term test is not a good predictor of the long-term response.
Keywords
Adolescent
Blood Urea Nitrogen
Body Height/drug effects
Child
Child, Preschool
Female
Growth/drug effects/physiology
Growth Hormone/deficiency/*therapeutic use
Humans
Insulin-Like Growth Factor I/*metabolism
Male
Recombinant Proteins/therapeutic use
Time Factors
Pubmed
Web of science
Create date
25/01/2008 11:30
Last modification date
20/08/2019 14:26