Fetal serum beta2-microglobulin predicts postnatal renal function in bilateral uropathies

Details

Serval ID
serval:BIB_37B0197C1050
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fetal serum beta2-microglobulin predicts postnatal renal function in bilateral uropathies
Journal
Kidney International
Author(s)
Dommergues  M., Muller  F., Ngo  S., Hohlfeld  P., Oury  J. F., Bidat  L., Mahieu-Caputo  D., Sagot  P., Body  G., Favre  R., Dumez  Y.
ISSN
0085-2538 (Print)
Publication state
Published
Issued date
07/2000
Volume
58
Number
1
Pages
312-6
Notes
Journal Article --- Old month value: Jul
Abstract
BACKGROUND: Predicting postnatal renal function is crucial for the prenatal evaluation of fetal bilateral uropathies. Prenatal ultrasound can identify intrauterine terminal renal failure, but is not sensitive enough to identify those infants who would survive with an impaired renal function. Because it reflects fetal glomerular filtration, fetal serum beta2-microglobulin is a potential predictor of postnatal renal function. METHODS: Fetal serum beta2-microglobulin (beta2m) was assayed in 61 cases of bilateral or low obstructive uropathy, 74 controls, and 17 cases of bilateral renal agenesis, and was correlated with renal function. RESULTS: Fetal serum beta2m was 3.2 mg/L (range 1.5 to 4.7) in controls (N = 74), 9.5 mg/L (range 6.7 to 11.3) in bilateral renal agenesis (N = 17), 7 mg/L (5.1 to 10.6) in uropathy in which terminal renal failure resulted in termination of pregnancy (N = 26), and 3.7 mg/L (range 2.3 to 11.2) in live births with uropathy (N = 35). In the latter subgroup, fetal serum beta2m was significantly and positively correlated (r2 = 0.91) with postnatal serum creatinine. All survivors with a postnatal serum creatinine < or =50 micromol/L ha a fetal serum beta2m lower than 5 mg/L. Four of 6 survivors with a postnatal serum creatinine> 50 micromol/L had a fetal serum beta2m greater than 5 mg/L. CONCLUSION: Fetal serum beta2-microglobulin is a marker for renal function and predicts postnatal serum creatinine in bilateral or low fetal obstructive uropathy.
Keywords
Biological Markers Child, Preschool Creatinine/blood Female Glomerular Filtration Rate Humans Infant Infant, Newborn Kidney/abnormalities/*physiology Predictive Value of Tests Pregnancy *Prenatal Diagnosis Ureter/abnormalities Ureteral Obstruction/*blood Urethra/abnormalities Urethral Obstruction/*blood beta 2-Microglobulin/*blood
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:12
Last modification date
20/08/2019 14:26
Usage data