The evolution of chemoradiation for glioblastoma: a modern success story
Details
Serval ID
serval:BIB_379DED2944F0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The evolution of chemoradiation for glioblastoma: a modern success story
Journal
Current Oncology Reports
ISSN
1523-3790 (Print)
Publication state
Published
Issued date
01/2006
Volume
8
Number
1
Pages
50-3
Notes
Journal Article
Review --- Old month value: Jan
Review --- Old month value: Jan
Abstract
The dismal prognosis of glioblastoma had remained unchanged for the past 30 years until the association of temozolomide and radiotherapy in the breakthrough European Organization for Cancer/National Cancer Institute of Canada (EORTC/NCIC) trial brought new hope for patients. This trial will serve as a platform for new and exciting clinical and translational research areas. We review here the role of standard radiotherapy and chemotherapy in glioblastoma and the potential causes of their failure, and we focus on some of the aspects that led to the successful EORTC/NCIC trial and some of the related studies.
Keywords
Antineoplastic Agents, Alkylating/*therapeutic use
Brain Neoplasms/*drug therapy/*radiotherapy/surgery
Chemotherapy, Adjuvant
Dacarbazine/*analogs & derivatives/therapeutic use
Female
Glioblastoma/*drug therapy/*radiotherapy
Humans
Male
Radiotherapy, Adjuvant
Randomized Controlled Trials
Pubmed
Create date
24/01/2008 17:12
Last modification date
20/08/2019 13:26
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