Molecular tracking of antigen-specific T-cell clones during immune responses.
Details
Serval ID
serval:BIB_37953
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Molecular tracking of antigen-specific T-cell clones during immune responses.
Journal
Current Opinion in Immunology
ISSN
0952-7915
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
17
Number
4
Pages
441-447
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Despite extended international efforts, the mechanisms governing T-cell receptor repertoire selection and kinetics in response to foreign or tumour antigens remain poorly characterized. A central goal of current research is to develop improved, reliable, immunological monitoring methods that measure and combine such parameters as the frequency of antigen-specific T cells and their functional capacities, as well as their clonal expansion during immune responses. Detecting and tracking defined anti-viral- and anti-tumour-specific T-cell responses ex vivo should lead to improvements in therapeutic strategies against viral infection or cancer in the future. During the past few years, highly sensitive tools have been developed to enable the molecular dissection and tracking of clonal T-cell expansion in animal models as well as in humans.
Keywords
Animals, Antibodies, Monoclonal/immunology, Antigens/immunology, Complementarity Determining Regions/genetics, Complementarity Determining Regions/immunology, Humans, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology
OAI-PMH
Pubmed
Web of science
Create date
19/11/2007 12:36
Last modification date
20/08/2019 13:26