Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study.

Details

Serval ID
serval:BIB_37759BE0E5D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study.
Journal
Obesity surgery
Author(s)
de La Harpe R., Rüeger S., Kutalik Z., Ballabeni P., Suter M., Vionnet N., Laferrère B., Pralong F.
ISSN
1708-0428 (Electronic)
ISSN-L
0960-8923
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
30
Number
4
Pages
1332-1338
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Roux en Y gastric bypass surgery (RYGB) is an effective therapy for patients with severe obesity. It induces both significant weight loss and rapid improvements of metabolic complications. This study was undertaken to better define the direct role of weight loss in the metabolic improvements.
A retrospective, case-control study of a cohort of 649 patients with obesity who underwent RYGB, comparing higher and lower responders at 2 years after surgery (n = 100 pairs). Pairs of patients were matched for age, gender, and initial BMI. The rates of remission of diabetes, hypertension, dyslipidemia, and hyperuricemia were compared using a mixed effects logistic regression analysis.
Diabetes before surgery was present in 12/100 lower responders and 17/100 higher responders. Remission at 2 years was observed in 4/12 (33%) of lower responders, compared to 15/17 (88%) of higher responders. Thus, the odds of diabetes remission was significantly smaller in lower responders (OR = 0.067, 95% CI 0.01-0.447). A mixed model regression analysis of all the parameters for each patient showed that the odds of achieving remission of any comorbidity was significantly lower in lower responders (OR = 0.62, 95% CI = 0.39-0.97).
We could demonstrate that weight loss is a significant determinant of the remission of diabetes 2 years after RYGB. These data underline the importance of weight loss in the benefits of this procedure.
Keywords
Metabolic comorbidities, Obesity, Remission of diabetes mellitus, Roux-en-y gastric bypass surgery, Weight loss
Pubmed
Web of science
Create date
06/12/2019 12:37
Last modification date
28/07/2020 6:21
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