Response Types and Factors Associated with Response Types to Biologic Therapies in Patients with Moderate-to-Severe Plaque Psoriasis from Two Randomized Clinical Trials.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_3774E7C2AE70
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Response Types and Factors Associated with Response Types to Biologic Therapies in Patients with Moderate-to-Severe Plaque Psoriasis from Two Randomized Clinical Trials.
Journal
Dermatology and therapy
Author(s)
Egeberg A., Conrad C., Gorecki P., Wegner S., Buyze J., Acciarri L., Thaçi D.
ISSN
2193-8210 (Print)
Publication state
Published
Issued date
03/2024
Peer-reviewed
Oui
Volume
14
Number
3
Pages
745-758
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
This study aimed to understand treatment response dynamics, including factors associated with favorable response, among patients with moderate-to-severe psoriasis who received guselkumab, adalimumab, or secukinumab.
These post hoc analyses used data from the phase III clinical trials ECLIPSE and VOYAGE 1, which were conducted between September 2021 and November 2022. On the basis of absolute Psoriasis Area and Severity Index (aPASI) scores, patients were divided into short-term response types (SRT1-6, based on week 20-48 response) and long-term response types (LRT1-4, based on week 52-252 response). Response types (RTs) were based on aPASI cutoffs deemed clinically relevant by the investigators; SRT1/LRT1 were the most favorable response types. Baseline characteristics were compared across RTs, and logistic regression analyses established factors associated with SRT1/LRT1.
Overall, 1045, 662, and 272 patients were included in the ECLIPSE short-term, VOYAGE 1 short-term, and VOYAGE 1 long-term analyses, respectively. Mean age, body mass index (BMI), baseline aPASI score, and body surface area were lower in SRT1 than SRT6. In VOYAGE 1, adalimumab treatment, high BMI, and current/former smoking status resulted in less favorable responses. In the VOYAGE 1 long-term analysis, patients in LRT4 had the highest baseline aPASI score, were older, and were more often obese compared with other LRT groups. Regression analyses showed that SRT1 (both treatments) in VOYAGE 1 and ECLIPSE, and LRT1 (guselkumab group) in the VOYAGE 1 long-term analysis, were associated with week 16 aPASI response. In VOYAGE 1, SRT1 was associated with psoriasis duration and smoking status.
Early treatment response and baseline characteristics, including smoking, psoriasis duration, and obesity, may be associated with longer-term response to biologics.
ECLIPSE: NCT03090100, VOYAGE 1: NCT02207231.
Keywords
Adalimumab, Baseline factors, Guselkumab, Psoriasis, Response dynamics, Secukinumab, Treatment response
Pubmed
Web of science
Open Access
Yes
Create date
18/03/2024 18:02
Last modification date
06/04/2024 7:27
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