Clinical translation of FLASH radiotherapy: Why and how?

Details

Serval ID
serval:BIB_37467C7CDBF5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical translation of FLASH radiotherapy: Why and how?
Journal
Radiotherapy and oncology
Author(s)
Bourhis J., Montay-Gruel P., Gonçalves Jorge P., Bailat C., Petit B., Ollivier J., Jeanneret-Sozzi W., Ozsahin M., Bochud F., Moeckli R., Germond J.F., Vozenin M.C.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
10/2019
Peer-reviewed
Oui
Volume
139
Pages
11-17
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical trial have recently shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. In the present review, we summarize the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters and the potential technologies needed for a successful clinical translation.
Keywords
Animals, Humans, Neoplasms/radiotherapy, Radiotherapy/methods, Radiotherapy Dosage, Clinical trial, Differential effect, FLASH-radiotherapy, Normal tissue protection
Pubmed
Web of science
Create date
18/07/2019 16:56
Last modification date
20/06/2020 5:18
Usage data