Metformine: nouvelles données pour une ancienne molecule [Metformin: new data for an old molecule].

Details

Serval ID
serval:BIB_3743779B7147
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Metformine: nouvelles données pour une ancienne molecule [Metformin: new data for an old molecule].
Journal
Revue Médicale Suisse
Author(s)
Sanduloviciu M., Jornayvaz F.R.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2015
Volume
11
Number
477
Pages
1222-1226
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
Metformin is the first-line oral agent for the treatment of type 2 diabetes according to the guidelines. Metformin decreases hepatic glucose production, does not induce weight gain and does not increase the risk of hypoglycemia. However, decades after its introduction, its mode of action has been only recently highlighted. The side effects of metformin are well known and consist primarily of digestive problems. Although rare, the dreaded complication is lactic acidosis, which can develop in patients with severe renal insufficiency or in conditions of low perfusion. The purpose of this article is to review the indications, risks and benefits of this drug, but also to discuss new evidence related to its mechanism of action and the conditions that increase the risk of lactic acidosis.
Keywords
Blood Glucose/drug effects, Body Weight/drug effects, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/prevention & control, Diabetes Mellitus, Type 2/drug therapy, Humans, Hypoglycemic Agents/therapeutic use, Incidence, Metformin/therapeutic use, Neoplasms/epidemiology, Neoplasms/prevention & control, Obesity/drug therapy
Pubmed
Create date
10/09/2015 11:51
Last modification date
20/08/2019 13:25
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