Long-term Efficacy of TNF-alpha Inhibitors on Persistent Uveitic Macular Edema: A Swiss Multicenter Cohort Study.

Details

Serval ID
serval:BIB_3742A8D722D8
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Long-term Efficacy of TNF-alpha Inhibitors on Persistent Uveitic Macular Edema: A Swiss Multicenter Cohort Study.
Journal
Ocular immunology and inflammation
Author(s)
Bograd A., Fuchs D., Bächtiger J., Pfister I.B., Spindler J., Hoogewoud F., Gugleta K., Böni C., Guex-Crosier Y., Garweg J.G., Tappeiner C.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
In Press
Peer-reviewed
Oui
Pages
1-8
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To assess the efficacy of tumor necrosis factor-alpha inhibitors (TNFi) on uveitic macular edema (ME) unresponsive to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).
This multicenter retrospective study included patients with uveitic ME persisting despite csDMARDs. The effect of an additional TNFi on central retinal thickness (CRT), best corrected visual acuity (BCVA) and corticosteroid need was evaluated.
Thirty-five eyes (26 patients, mean age 42.9 ± 15.2 years) were included. CRT decreased from 425 ± 137 µm to 294 ± 66 µm (p < .001) and 280 ± 48 µm (p < .001) at 1 and 4 years of follow-up, respectively. BCVA improved from 0.28 ± 0.22 to 0.21 ± 0.48 (1 year, p = .013) and 0.08 ± 0.13 logMAR (4 years, p = .002). The proportion of patients requiring systemic corticosteroids decreased from 88.5% to 34.8% (1 year) and 15.4% (4 years).
The addition of a TNFi resulted in an improvement of CRT and BCVA for up to 4 years in uveitic ME but rescue treatments were needed for some patients.
Keywords
Adalimumab, TNF-alpha inhibitors, infliximab, macular edema, uveitis
Pubmed
Web of science
Create date
24/05/2022 8:58
Last modification date
02/07/2022 6:34
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