BAFF is a survival and maturation factor for mouse B cells.

Details

Serval ID
serval:BIB_373D40BF5A2E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BAFF is a survival and maturation factor for mouse B cells.
Journal
European Journal of Immunology
Author(s)
Rolink A.G., Tschopp J., Schneider P., Melchers F.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Publication state
Published
Issued date
2002
Volume
32
Number
7
Pages
2004-2010
Language
english
Abstract
Human B cell-activating factor (BAFF) induces mouse surface IgM+ B cells of the immature type from bone marrow and of the immature types 1 and 2 from spleen, as well as of the mature type from spleen to increased longevity in tissue culture. BAFF does so polyclonally and without inducing proliferation in any of these B cell subpopulations. BAFF induces phenotypic and functional maturation of immature to mature B cells so that all immature cells loose C1qRp (AA4.1, 493) expression and type 1 immature cells up-regulate IgD, CD21 and CD23. Immature B cells of types 1 and 2, upon pre-incubation with BAFF, change their reactiveness to Ig-specific antibodies so that they no longer enter apoptosis but now proliferate. However, BAFF does not seem to overcome negative selection of developing immature B cells in vitro.
Keywords
Animals, B-Cell Activating Factor, B-Lymphocytes/cytology, B-Lymphocytes/drug effects, Cell Differentiation/drug effects, Cell Division, Cell Survival/drug effects, Cells, Cultured, Humans, Membrane Proteins/pharmacology, Mice, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:19
Last modification date
20/08/2019 13:25
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