Chromosomal imbalances in noninvasive papillary bladder neoplasms (pTa).

Details

Serval ID
serval:BIB_372A295CB278
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chromosomal imbalances in noninvasive papillary bladder neoplasms (pTa).
Journal
Cancer research
Author(s)
Zhao J., Richter J., Wagner U., Roth B., Schraml P., Zellweger T., Ackermann D., Schmid U., Moch H., Mihatsch M.J., Gasser T.C., Sauter G.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Publication state
Published
Issued date
15/09/1999
Peer-reviewed
Oui
Volume
59
Number
18
Pages
4658-4661
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Almost 70% of urinary bladder neoplasms present as low-grade papillary noninvasive tumors (stage pTa). To determine which genomic alterations can occur in pTa tumors of different grades and to evaluate the prognostic significance of chromosomal imbalances, we analyzed 113 pTa tumors (40 grade 1, 55 grade 2, 18 grade 3) by comparative genomic hybridization. pTaG1 (1.9 +/- 2.0) and pTaG2 (3.1 +/- 2.9) tumors had only few genomic alterations with 9q- (44%), 9p- (36%), and -Y (21%) being most prevalent. Neither the total number of aberrations nor any individual alteration was linked to the risk of recurrence in 95 pTaG1/G2 tumors with clinical follow-up information. pTaG3 tumors were characterized by a high number of alterations (7.7 +/- 4.5; P < 0.0001 for G3 versus G2). Several chromosomal imbalances that have previously been reported to be typical for invasive bladder neoplasms were significantly more frequent in pTaG3 than in pTaG2 tumors, including 2q-, 5p+, 5q-, 6q-, 8p-, 10q-, 18q-, and 20q+. A malfunction of genes at these loci may contribute to the development of high-grade urothelial neoplasias. However, there is no evidence for a direct role of these alterations for development of invasive tumor growth.
Keywords
Carcinoma in Situ/genetics, Carcinoma in Situ/pathology, Carcinoma, Papillary/genetics, Carcinoma, Papillary/pathology, Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 9, Disease-Free Survival, Humans, Loss of Heterozygosity, Neoplasm Staging, Prognosis, Recurrence, Urinary Bladder Neoplasms/genetics, Urinary Bladder Neoplasms/pathology
Pubmed
Web of science
Create date
08/01/2021 19:36
Last modification date
09/01/2021 6:26
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