Le mieux, ennemi du bien ?

Details

Serval ID
serval:BIB_371E391E5644
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Institution
Title
Le mieux, ennemi du bien ?
Journal
Revue medicale suisse
Author(s)
Dory E.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
31/08/2016
Peer-reviewed
Oui
Volume
12
Number
528
Pages
1444
Language
french
Notes
Publication types: News
Publication Status: ppublish
Abstract
The close association of obesity with an increased risk of metabolic diseases, such as insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease, is now well established. In this review, we aim first to describe the inflammatory process activated in response to overnutrition, especially in the liver and the adipose tissue. We then discuss the systemic effects of low-grade inflammation on the onset of insulin resistance. Particular attention is given to a series of very recent reports that identify not only processes but also molecules (lipids and metabolites) that interfere with the normal insulin signaling. Finally, special notes concerning the roles of peroxisome proliferator-activated receptors in the various processes will be made.

Keywords
PPARs, insulin resistance, liver-adipose tissue cross-talk, metaflammation, visceral white adipose tissue
Pubmed
Create date
26/07/2017 14:13
Last modification date
20/08/2019 13:25
Usage data