Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.

Details

Serval ID
serval:BIB_36FC7B9B00A2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.
Journal
Genomics
Author(s)
Mooser V., Maillard A., Bonny C., Steinmann M., Shaw P., Yarnall D.P., Burns D.K., Schorderet D.F., Nicod P., Waeber G.
ISSN
0888-7543
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
55
Number
2
Pages
202-8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Islet-brain 1 (IB1), a regulator of the pancreatic beta-cell function in the rat, is homologous to JIP-1, a murine inhibitor of c-Jun amino-terminal kinase (JNK). Whether IB1 and JIP-1 are present in humans was not known. We report the sequence of the 2133-bp human IB1 cDNA, the expression, structure, and fine-mapping of the human IB1 gene, and the characterization of an IB1 pseudogene. Human IB1 is 94% identical to rat IB1. The tissue-specific expression of IB1 in human is similar to that observed in rodent. The IB1 gene contains 12 exons and maps to chromosome 11 (11p11.2-p12), a region that is deleted in DEFECT-11 syndrome. Apart from an IB1 pseudogene on chromosome 17 (17q21), no additional IB1-related gene was found in the human genome. Our data indicate that the sequence and expression pattern of IB1 are highly conserved between rodent and human and provide the necessary tools to investigate whether IB1 is involved in human diseases.
Keywords
Adaptor Proteins, Signal Transducing, Animals, Base Sequence, Blotting, Northern, Blotting, Southern, Carrier Proteins, Chromosome Mapping, Chromosomes, Bacterial, Chromosomes, Human, Pair 11, DNA, Complementary, Exons, Humans, In Situ Hybridization, Fluorescence, Introns, Mice, Molecular Sequence Data, Nuclear Proteins, Pseudogenes, Rats, Sequence Analysis, DNA, Tissue Distribution, Trans-Activators
Pubmed
Web of science
Create date
17/11/2008 8:57
Last modification date
20/08/2019 13:25
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