Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations.

Details

Serval ID
serval:BIB_36F8DFAD1356
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations.
Journal
Genome biology
Author(s)
Babur Ö., Gönen M., Aksoy B.A., Schultz N., Ciriello G., Sander C., Demir E.
ISSN
1474-760X (Electronic)
ISSN-L
1474-7596
Publication state
Published
Issued date
26/02/2015
Peer-reviewed
Oui
Volume
16
Pages
45
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.
Keywords
Breast Neoplasms/etiology, Breast Neoplasms/genetics, Breast Neoplasms/pathology, Computational Biology, Databases, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Genomics, Humans, Neoplasm Proteins/biosynthesis, Neoplasm Proteins/genetics, Signal Transduction/genetics
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2018 11:02
Last modification date
20/01/2021 6:26
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