Unusual cause of bilateral optic disc swelling: POEMS syndrome.

Details

Serval ID
serval:BIB_36EF67ECA973
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Unusual cause of bilateral optic disc swelling: POEMS syndrome.
Journal
Klinische Monatsblätter für Augenheilkunde
Author(s)
Wiaux C., Landau K., Borruat F.X.
ISSN
0023-2165
Publication state
Published
Issued date
04/2007
Peer-reviewed
Oui
Volume
224
Number
4
Pages
334-6
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
BACKGROUND: POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) is a rare disorder associated with plasma cell disorder. Optic disc swelling can be present, and macular oedema has been reported once before. PATIENTS AND METHODS: Three patients with POEMS syndrome were investigated. Lumbar puncture and neuro-ophthalmic examination were performed on all patients. RESULTS: Visual symptoms included decreased vision, photopsia and blurred vision. Optic disc swelling was present in all three patients. Visual acuity was decreased in only one patient (0.2 in right eye, 0.7 in left eye) due to macular oedema, and another patient with normal visual acuity showed also a mild macular oedema on fluorescein angiography. In these two patients, elevated intracranial pressure was found (30 and 39 cm H(2)O, respectively). The macular oedema disappeared under steroids and acetazolamide therapy with visual improvement, but optic disc swelling remained. CONCLUSION: Optic disc swelling is frequent in POEMS and macular oedema may be more frequently present than previously thought. Interestingly macular oedema was detected in the two patients with increased intracranial pressure.
Keywords
Adult, Female, Humans, Male, Middle Aged, POEMS Syndrome/diagnosis, POEMS Syndrome/therapy, Papilledema/complications, Papilledema/diagnosis, Rare Diseases/complications, Rare Diseases/diagnosis, Treatment Outcome
Pubmed
Web of science
Create date
28/01/2008 12:37
Last modification date
20/08/2019 13:25
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