Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3.

Details

Serval ID
serval:BIB_36ECCCB62BF1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3.
Journal
Clinical Microbiology and Infection
Author(s)
Singh P., Benjak A., Carat S., Kai M., Busso P., Avanzi C., Paniz-Mondolfi A., Peter C., Harshman K., Rougemont J., Matsuoka M., Cole S.T.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
2014
Volume
20
Number
10
Pages
O619-O622
Language
english
Abstract
Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M. leprae.
Keywords
Leprosy, molecular epidemiology, Mycobacterium leprae, rifampicin-resistance, single nucleotide polymorphism
Pubmed
Web of science
Open Access
Yes
Create date
02/01/2015 9:38
Last modification date
20/08/2019 13:25
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