Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.

Details

Serval ID
serval:BIB_36B0DD3E30A1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Journal
Journal of gastrointestinal and liver diseases
Author(s)
Tehranian S., Treglia G., Krag D.N., Dabbagh Kakhki V.R., Zakavi S.R., Sadeghi R., Keshtgar M.
ISSN
1842-1121 (Electronic)
ISSN-L
1841-8724
Publication state
Published
Issued date
09/2013
Peer-reviewed
Oui
Volume
22
Number
3
Pages
321-328
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The pathological condition of inguinal lymph nodes is an independent prognostic factor in predicting tumor recurrence and overall survival in anal canal cancer. Sentinel node mapping is a non-invasive method for the detection of inguinal lymph node involvement in anal cancer. In the current study, we conducted a comprehensive search of literature in this regard and then interpreted the final results in a systematic review and meta-analysis format.
Medline, SCOPUS, and ISI Web of Knowledge were searched with the following search terms: (anal OR anus) AND sentinel. Outcomes of interest were inguinal detection rate and inguinal recurrence in patients receiving inguinal sparing radiotherapy due to pathologically negative inguinal sentinel nodes (false negative cases).
Overall 16 studies (323 patients) were included in the meta-analysis. Pooled inguinal detection rate was 86.2%: 73.4-93.4%: for studies using both blue dye and radiotracer it was 90.1% [78.7-95.8] and for studies using radiotracer alone it was 72.4% [46.3-88.9]. Pooled sensitivity was 90% [79-97%].
Sentinel node biopsy is a promising method for inguinal lymph node staging in anal cancer. Combined blue dye and radiotracer technique can maximize the inguinal detection rate. Location of the tumor is highly associated with the detection of inguinal sentinel nodes. Despite fairly high pooled sensitivity, no definite conclusion can be made regarding false negative rate of this technique due to low sample size and sub-optimal quality of the included studies. Large multicenter studies with long and consistent follow up are needed to definitely validate this technique in the future.

Keywords
Anus Neoplasms/pathology, Coloring Agents, Dye Dilution Technique, Humans, Lymph Nodes/pathology, Lymphatic Metastasis, Neoplasm Staging, Predictive Value of Tests, Sentinel Lymph Node Biopsy
Pubmed
Web of science
Create date
20/08/2017 19:12
Last modification date
20/08/2019 13:24
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