Human papillomavirus infection in malignant and benign gynaecological conditions: a study in Greek women.

Details

Serval ID
serval:BIB_36A597A8A829
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human papillomavirus infection in malignant and benign gynaecological conditions: a study in Greek women.
Journal
Health care for women international
Author(s)
Konidaris S., Kouskouni E.E., Panoskaltsis T., Kreatsas G., Patsouris E.S., Sarivalassis A., Nonni A., Lazaris A.C.
ISSN
0739-9332 (Print)
ISSN-L
0739-9332
Publication state
Published
Issued date
02/2007
Peer-reviewed
Oui
Volume
28
Number
2
Pages
182-191
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
HPV infection is by far the most frequent sexually transmitted disease. Our aim in this prospective nonrandomized study was to investigate the frequency with which different subtypes of the human papillomavirus (HPV) are found in gynaecological malignant and benign conditions and to compare the rate of infection between them. Detailed data of 195 women were selected and divided into three groups. The first group consisted of specimens from 68 women with cervical cancer. The second group consisted of specimens from 43 women with endometrial and ovarian cancer. The third group consisted of 84 specimens from women who were operated on for benign gynaecological diseases. Seven oncogenic types of HPV (6, 11 [low-risk subtypes] 16, 18, 31, 33, and 51 [high-risk subtypes]) were investigated by using the in situ hybridization technique. The HPV detection rate was higher in the cervical cancer group (74.8%), compared with the second (27.9%) and third (45.2%) groups. The most common HPV subtypes in the first group were 16 and 18. The most common subtypes in the second group were the 31, 33, and 51, and in the third group the 6 and 11 subtypes. Women developed cervical cancer at a younger age than endometrial or ovarian cancer. Smoking and exposure to multiple sexual partners appeared related to the development of cervical cancer. The use of contraceptive pill, dietary habits, and diabetes did not seem to increase the risk of HPV infection in this population. As it is common in other populations, in this selected population of Greek women we were able to confirm that in women with cervical cancer the most common HPV subtypes are 16 and 18. Education of adolescents on the epidemiological association of smoking and unprotected intercourse with cervical cancer will certainly help to reduce the rates of development of preinvasive and invasive cancer of the cervix in young women.
Keywords
Adult, Aged, Chi-Square Distribution, Cross-Sectional Studies, Endometrial Neoplasms/epidemiology, Endometrial Neoplasms/virology, Female, Greece/epidemiology, Humans, In Situ Hybridization, Middle Aged, Ovarian Neoplasms/epidemiology, Ovarian Neoplasms/virology, Papillomaviridae/classification, Papillomaviridae/isolation & purification, Papillomavirus Infections/complications, Papillomavirus Infections/epidemiology, Prospective Studies, Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms/virology, Women's Health
Pubmed
Create date
24/08/2021 10:32
Last modification date
25/08/2021 5:37
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