Motor sequence learning: a study with positron emission tomography.

Details

Serval ID
serval:BIB_36A42572F353
Type
Article: article from journal or magazin.
Collection
Publications
Title
Motor sequence learning: a study with positron emission tomography.
Journal
Journal of Neuroscience
Author(s)
Jenkins I.H., Brooks D.J., Nixon P.D., Frackowiak R.S., Passingham R.E.
ISSN
0270-6474 (Print)
ISSN-L
0270-6474
Publication state
Published
Issued date
1994
Volume
14
Number
6
Pages
3775-3790
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
We have used positron emission tomography to study the functional anatomy of motor sequence learning. Subjects learned sequences of keypresses by trial and error using auditory feedback. They were scanned with eyes closed under three conditions: at rest, while performing a sequence that was practiced before scanning until overlearned, and while learning new sequences at the same rate of performance. Compared with rest, both sequence tasks activated the contralateral sensorimotor cortex to the same extent. Comparing new learning with performance of the prelearned sequence, differences in activation were identified in other areas. (1) Prefrontal cortex was only activated during new sequence learning. (2) Lateral premotor cortex was significantly more activated during new learning, whereas the supplementary motor area was more activated during performance of the prelearned sequence. (3) Activation of parietal association cortex was present during both motor tasks, but was significantly greater during new learning. (4) The putamen was equally activated by both conditions. (5) The cerebellum was activated by both conditions, but the activation was more extensive and greater in degree during new learning. There was an extensive decrease in the activity of prestriate cortex, inferotemporal cortex, and the hippocampus in both active conditions, when compared with rest. These decreases were significantly greater during new learning. We draw three main conclusions. (1) The cerebellum is involved in the process by which motor tasks become automatic, whereas the putamen is equally activated by sequence learning and retrieval, and may play a similar role in both. (2) When subjects learn new sequences of motor actions, prefrontal cortex is activated. This may reflect the need to generate new responses. (3) Reduced activity of areas concerned with visual processing, particularly during new learning, suggests that selective attention may involve depressing the activity of cells in modalities that are not engaged by the task.
Keywords
Adult, Brain/radionuclide imaging, Cerebrovascular Circulation, Humans, Learning/physiology, Male, Middle Aged, Motor Activity/physiology, Rest, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 20:50
Last modification date
20/08/2019 13:24
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