Les combinaisons fixes de medicaments antihypertenseurs. [Fixed antihypertensive drug combinations]

Details

Serval ID
serval:BIB_368BFAA4714F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Les combinaisons fixes de medicaments antihypertenseurs. [Fixed antihypertensive drug combinations]
Journal
Therapeutische Umschau
Author(s)
Waeber B.
ISSN
0040-5930
Publication state
Published
Issued date
1999
Volume
56
Number
1
Pages
33-6
Language
french
Notes
English Abstract
Journal Article
Review
Abstract
Arterial hypertension is a highly heterogeneous condition. It is therefore not surprising that blood pressure lowering agents acting via a given mechanism allow a normalization of blood pressure in a fraction of hypertensive subjects only. The combination of drugs with different mechanisms of action on the cardiovascular system results in a considerably higher antihypertensive efficacy, not only with regard to the absolute blood pressure reduction but also in the number of responders. This effect is not achieved at the expenses of tolerance, because usually lower doses of the combined agents are sufficient to achieve the target blood pressure. The administration of antihypertensive agents in fixed combination has the advantage of its simplicity for both the physician as well as the patient. This aspect also explains the increasing popularity of fixed combinations as a valuable option in the initial treatment of the hypertensive patient.
Keywords
Antihypertensive Agents/*administration & dosage/adverse effectsDrug Therapy, CombinationHumansHypertension/*drug therapy/etiologyTreatment Outcome
Pubmed
Create date
06/03/2009 12:00
Last modification date
20/08/2019 13:24
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