Angiotensin-II receptor blockers: benefits beyond blood pressure reduction?

Details

Serval ID
serval:BIB_36880
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiotensin-II receptor blockers: benefits beyond blood pressure reduction?
Journal
Journal of Human Hypertension
Author(s)
Volpe M., Ruilope L.M., McInnes G.T., Waeber B., Weber M.A.
ISSN
0950-9240
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
19
Number
5
Pages
331-339
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
Effective treatment of hypertension is essential to reduce the risk of renal and cardiovascular (CV) morbidity. The risks associated with hypertension are modulated by the presence of other factors. This has prompted the quest for agents that have benefits beyond blood pressure (BP) lowering. The angiotensin II receptor blocker (ARB) class of antihypertensive agents represents an important addition to the therapeutic options for elevated BP. Their ability to control BP is equivalent to existing therapies and there is a considerable and mounting evidence-base for their ability to reduce hypertension-associated target organ damage and comorbidities. Studies show that ARBs have clinical benefits across the spectrum of disease severity. In particular, recent large studies have demonstrated that these benefits extend to patients with conditions predisposing to CV events, such as diabetes, left ventricular hypertrophy and microalbuminuria, and where risk factors coexist. Data from these studies suggest that the CV protective effects of ARBs are at least, in part, independent from the BP lowering action. In addition, ARBs are extremely well tolerated, and strong evidence suggests that compliance with therapy--a key factor in achieving adequate BP control--with ARBs is higher than with other antihypertensive agents. Furthermore, flexible dosing and good tolerability profile mean that, where necessary, ARBs can be combined with other classes of antihypertensive agents to achieve adequate BP control and reduce the risk of hypertension-associated morbidity.
Keywords
Angiotensin II Type 1 Receptor Blockers, Blood Pressure, Humans, Hypertension, Risk Factors, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:35
Last modification date
20/08/2019 13:24
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