A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults.
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UNIL restricted access
State: Public
Version: author
Serval ID
serval:BIB_3679008B6EB8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults.
Journal
Journal of Affective Disorders
ISSN
1573-2517[electronic], 0165-0327[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
127
Number
1-3
Pages
316-320
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
INTRODUCTION: We have developed ultra-high risk criteria for bipolar affective disorder (bipolar at-risk - BAR) which include general criteria such as being in the peak age range of the onset of the disorder and a combination of specific criteria including sub-threshold mania, depressive symptoms, cyclothymic features and genetic risk. In the current study, the predictive validity of these criteria were tested in help-seeking adolescents and young adults. METHOD: This medical file-audit study was conducted at ORYGEN Youth Health (OYH), a public mental health program for young people aged between 15 and 24years and living in metropolitan Melbourne, Australia. BAR criteria were applied to the intake assessments of all non-psychotic patients who were being treated in OYH on 31 January, 2008. All entries were then checked for conversion criteria. Hypomania/mania related additions or alterations to existing treatments or initiation of new treatment by the treating psychiatrist served as conversion criteria to mania. RESULTS: The BAR criteria were applied to 173 intake assessments. Of these, 22 patients (12.7%) met BAR criteria. The follow-up period of the sample was 265.5days on average (SD 214.7). There were significantly more cases in the BAR group (22.7%, n=5) than in the non-BAR group (0.7%, n=1) who met conversion criteria (p<.001). CONCLUSIONS: These findings support the notion that people who develop a first episode of mania can be identified during the prodromal phase. The proposed criteria need further evaluation in prospective clinical trials.
Pubmed
Web of science
Create date
23/11/2010 15:43
Last modification date
20/08/2019 14:24