Early diagnosis of invasive candidiasis with mannan antigenemia and antimannan antibodies.

Details

Serval ID
serval:BIB_36702
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early diagnosis of invasive candidiasis with mannan antigenemia and antimannan antibodies.
Journal
Diagnostic Microbiology and Infectious Disease
Author(s)
Prella M., Bille J., Pugnale M., Duvoisin B., Cavassini M., Calandra T., Marchetti O.
ISSN
0732-8893 (Print)
ISSN-L
0732-8893
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
51
Number
2
Pages
95-101
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Late treatment of invasive candidiasis (IC) results in severe complications and high mortality. New tools are needed for early diagnosis. We conducted a retrospective study to assess the diagnostic utility of mannan antigenemia (Mn) and antimannan antibodies (anti-Mn) in neutropenic cancer patients at high risk for candidiasis. Twenty-eight patients with IC (based on European Organization for Research and Treatment of Cancer and Mycoses Study Group definitions) and 25 controls were studied. Mn and anti-Mn were positive (> or = 0.25 ng/mL and > or = 5 AU/mL, respectively) in 25/28 (89%) patients with candidiasis and in 4/25 (16%) controls: sensitivity, 89%; specificity, 84%; positive predictive value, 86%; negative predictive value, 88%. In patients with hepatosplenic lesions, assessing Mn/anti-Mn shortened the median time of diagnosis of candidiasis when compared with imaging (9 versus 25 days after fever onset as first sign of infection; P < 0.001). Candidiasis was diagnosed before neutrophil recovery in 78% and 11% of cases with Mn/anti-Mn and radiology, respectively (P < 0.001). Mn and anti-Mn may be useful for early noninvasive diagnosis of IC.
Keywords
Adult, Aged, Antibodies, Fungal/analysis, Antibodies, Fungal/immunology, Candidiasis/diagnosis, Candidiasis/immunology, Case-Control Studies, Early Diagnosis, Female, Fungemia/diagnosis, Fungemia/immunology, Hematologic Neoplasms/diagnosis, Hematologic Neoplasms/immunology, Humans, Immunocompromised Host, Male, Mannans/diagnostic use, Mannans/immunology, Middle Aged, Opportunistic Infections/diagnosis, Prognosis, Reference Values, Retrospective Studies, Risk Assessment, Sensitivity and Specificity
Pubmed
Web of science
Create date
19/11/2007 12:34
Last modification date
20/08/2019 13:24
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