Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females.

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serval:BIB_36659E8E9115
Type
Article: article from journal or magazin.
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Publications
Institution
Title
Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females.
Journal
Journal of clinical medicine
Author(s)
Ulpiano Trillig A., Damianaki A., Hendriks-Balk M., Brito W., Garessus J., Burnier M., Wuerzner G., Pruijm M.
ISSN
2077-0383 (Print)
ISSN-L
2077-0383
Publication state
Published
Issued date
20/06/2023
Peer-reviewed
Oui
Volume
12
Number
12
Pages
4141
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
(1) Background: The renal microcirculation is essential to maintain the renal function, but its determinants in humans have been poorly studied. Contrast-enhanced ultrasound (CEUS) allows the non-invasive quantification of the cortical micro-perfusion at the bedside using the perfusion index (PI). The aims of this study were to assess whether differences exist in PI between healthy males and females and to identify clinical determinants associated with cortical micro-perfusion. (2) Methods: Healthy, normotensive volunteers (eGFR > 60 mL/min/1.73 m <sup>2</sup> , no albuminuria) underwent CEUS under standardized conditions with the destruction-reperfusion (DR) technique. The mean PI of four DR sequences was reported as the primary outcome measure (3) Results: A total of 115 subjects (77 females and 38 males) completed the study; the mean ± SD age was, respectively, 37.1 ± 12.2 and 37.1 ± 12.7 years in females and males, and the mean eGFR was 105.9 ± 15.1 and 91.0 ± 17.4 mL/min/1.73 m <sup>2</sup> . The PI (median) was higher in females than in males, i.e., 2705 (IQR 1641-3777) vs. 1965 (IQR 1294-3346) arbitrary units (a.u), p = 0.02). A correlation analysis showed positive associations between PI and eGFR, female sex, heart rate, plasma renin activity (PRA) and plasma aldosterone concentrations (PAC), negative associations with potassium, bicarbonate and systolic blood pressure, and no associations with age, body mass index and renal resistive index (RRI). In a multivariate linear regression analysis, only PRA remained significantly associated with PI. (4) Conclusions: Although the PI was higher among females, this association was no longer significant after adjustment for covariates. There was no difference in females tested during the follicular or the luteal phases. In conclusion, the PI was only weakly influenced by classic clinical variables, but was positively associated with PRA, suggesting that the renin-angiotensin system plays a role in the regulation of the cortical micro-perfusion in humans. Identifying which other factors contribute to the large variations in micro-perfusion across individuals needs further study.
Keywords
contrast-enhanced ultrasound, imaging technologies, kidney disease, perfusion index, plasma renin activity, renal microcirculation, sex
Pubmed
Web of science
Open Access
Yes
Create date
29/06/2023 15:03
Last modification date
23/01/2024 8:23
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