Regulation of gene expression by interferons: control of H-2 promoter responses.

Details

Serval ID
serval:BIB_3662EA5CBC21
Type
Article: article from journal or magazin.
Collection
Publications
Title
Regulation of gene expression by interferons: control of H-2 promoter responses.
Journal
Science
Author(s)
Korber B., Mermod N., Hood L., Stroynowski I.
ISSN
0036-8075[print], 0036-8075[linking]
Publication state
Published
Issued date
03/1988
Volume
239
Number
4845
Pages
1302-1306
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
The magnitude of the response to interferons and the requirement for individual elements in the promoter of the H-2Dd gene were shown to be cell-specific and dependent on the type of interferon used. Three DNA sequences in the promoter were found to bind murine nuclear factors. Two of these sequences are in functionally defined enhancer regions and also bind to the transcription factor AP-1. The third sequence is part of the region involved in interferon regulation and is homologous to the enhancer element of the interferon beta gene. A model for interferon regulation of H-2 promoters is discussed.
Keywords
Animals, Base Sequence, Cell Line, Enhancer Elements, Genetic, Gene Expression Regulation, H-2 Antigens/genetics, Interferon Type I/immunology, Interferon-gamma/immunology, Major Histocompatibility Complex, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Promoter Regions, Genetic
Pubmed
Web of science
Create date
24/01/2008 10:41
Last modification date
20/08/2019 13:24
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