Differential effects of (D)- and (L)-homocysteic acid on the membrane potential of cat caudate neurons in situ.

Details

Serval ID
serval:BIB_365CC98277EE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential effects of (D)- and (L)-homocysteic acid on the membrane potential of cat caudate neurons in situ.
Journal
Neuroscience
Author(s)
Herrling P.L., Maeder J., Meier C.L., Do K.Q.
ISSN
0306-4522 (Print)
ISSN-L
0306-4522
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
31
Number
1
Pages
213-217
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The enantiomers of homocysteic acid have been applied by microiontophoresis to neurons of the cat caudate nucleus in situ. The (L)-enantiomer elicited a bursty firing pattern similar to the one caused by N-methyl-D-aspartate, but differing from the N-methyl-D-aspartate pattern inasmuch as (L)-homocysteate induced depolarization shifts were shorter and had a smaller amplitude. (L)-Homocysteate induced excitations could be strongly inhibited by the selective N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid but they were less sensitive to this antagonist than N-methyl-D-aspartate itself. (D)-Homocysteate elicited a more regular firing pattern similar to the one caused by non-N-methyl-D-aspartate excitatory amino acids such as quisqualate. These excitations were only rarely inhibited by 2-amino-7-phosphonoheptanoic acid. Our results suggest that (L)-homocysteate, a transmitter candidate at central mammalian synapses, is a mixed excitatory amino acid agonist with a strong preference for N-methyl-D-aspartate receptors in the cat caudate nucleus, while (D)-homocysteate has a predominant action at non-N-methyl-D-aspartate excitatory amino acid receptors.
Keywords
2-Amino-5-phosphonovalerate/analogs & derivatives, Action Potentials/drug effects, Amino Acids/pharmacology, Animals, Cats, Caudate Nucleus/drug effects, Caudate Nucleus/physiology, Female, Homocysteine/analogs & derivatives, Homocysteine/pharmacology, Male, Membrane Potentials/drug effects, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter/drug effects, Receptors, Neurotransmitter/physiology, Stereoisomerism
Pubmed
Create date
06/03/2014 16:28
Last modification date
20/08/2019 13:24
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