Enhancement by diuretics of the antihypertensive action of long-term angiotensin converting enzyme blockade

Details

Serval ID
serval:BIB_364170FD6188
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enhancement by diuretics of the antihypertensive action of long-term angiotensin converting enzyme blockade
Journal
Clinical and Experimental Hypertension
Author(s)
Brunner  H. R., Gavras H., Waeber B.
ISSN
0148-3927
Publication state
Published
Issued date
1980
Volume
2
Number
3-4
Pages
639-57
Language
english
Notes
Journal Article
Abstract
Thirty-nine patients with various types of hypertension were treated by chronic blockage of the angiotensin converting enzyme, i.e. by twice daily administration of captopril, 50 to 200 mg p.o. The blood pressure reduction observed 1 hour following administration of the inhibitor was directly related to the baseline plasma renin activity (r=- 0.67, p < 0.001). Whenever blockade of the renin system alone did not lower blood pressure to normal levels additional sodium subtraction brought it under control. With the renin system neutralized, blood pressure becomes exquisitely sensitive to changes in sodium balance. Diuretics seem to preserve optimal natriuretic efficacy despite blood pressure reduction, probably because aldosterone levels are reduced and renal blood flow increases. Blockade of the renin system together with individually tailored salt subtraction provides an attractive new approach to long-term treatment of clinical hypertension.
Keywords
AdolescentAdultAged*Angiotensin-Converting Enzyme InhibitorsBlood Pressure/drug effectsCaptopril/*pharmacology/therapeutic useChildChlorthalidone/pharmacologyDiuretics/*pharmacology/therapeutic useDrug SynergismFemaleFurosemide/pharmacologyHumansHyperaldosteronism/drug therapyHypertension/blood/*drug therapyHypertension, Renovascular/drug therapyKidney Failure, Chronic/drug therapyMaleMiddle AgedMinoxidil/therapeutic useProline/*analogs & derivativesPropranolol/therapeutic useRenal DialysisRenin/bloodSodium/metabolism
Pubmed
Web of science
Create date
06/03/2009 12:00
Last modification date
20/08/2019 13:24
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