Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.

Details

Serval ID
serval:BIB_36205
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.
Journal
Journal of Virology
Author(s)
Joos B., Trkola A., Fischer M., Kuster H., Rusert P., Leemann C., Böni J., Oxenius A., Price D.A., Phillips R.E., Wong J.K., Hirschel B., Weber R., Günthard H.F.
ISSN
0022-538X
Publication state
Published
Issued date
2005
Volume
79
Number
14
Pages
9026-9037
Language
english
Notes
Publication types: Journal Article
Abstract
Genetic diversity of viral isolates in human immunodeficiency virus (HIV)-infected individuals varies substantially. However, it remains unclear whether HIV-related disease progresses more rapidly in patients harboring virus swarms with low or high diversity and, in the same context, whether high or low diversity is required to induce potent humoral and cellular immune responses. To explore whether viral diversity predicts virologic control, we studied HIV-infected patients who received antiretroviral therapy (ART) for years before undergoing structured treatment interruptions (STI). Viral diversity before initiation of ART and the ability of the patients to contain viremia after STI and final cessation of treatment was evaluated. Seven out of 21 patients contained plasma viremia at low levels after the final treatment cessation. Clonal sequences encompassing the envelope C2V3C3 domain derived from plasma prior to treatment, exhibited significantly lower diversity in these patients compared to those derived from patients with poor control of viremia. Viral diversity pre-ART correlated with the viral replication capacity of rebounding virus isolates during STI. Neutralizing antibody activity against autologous virus was significantly higher in patients who controlled viremia and was associated with lower pretreatment diversity. No such association was found with binding antibodies directed to gp120. In summary, lower pretreatment viral diversity was associated with spontaneous control of viremia, reduced viral replication capacity and higher neutralizing antibody titers, suggesting a link between viral diversity, replication capacity, and neutralizing antibody activity.
Keywords
Anti-HIV Agents/therapeutic use, Gene Products, env/genetics, HIV/classification, HIV/physiology, HIV Antibodies/blood, HIV Infections/drug therapy, HIV Infections/genetics, Humans, Phylogeny, T-Lymphocytes, Cytotoxic/immunology, Viremia/drug therapy, Viremia/virology, Virus Replication
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:34
Last modification date
20/08/2019 13:23
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