Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.

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Serval ID
serval:BIB_36167AA55407
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.
Journal
International Journal of Epidemiology
Author(s)
Marron Manuela, Boffetta Paolo, Zhang Zuo-Feng, Zaridze David G., Wünsch-Filho Victor, Winn Deborah M., Wei Qingyi, Talamini Renato, Szeszenia-Dabrowska Neonilia, Sturgis Erich M., Smith Elaine, Schwartz Stephen M., Rudnai Peter, Purdue Mark P., Olshan Andrew F., Eluf-Neto Jose, Muscat Joshua, Morgenstern Hal, Menezes Ana, McClean Michael D., Matos Elena, Mates Ioan Nicolae, Lissowska Jolanta, Levi Fabio, Lazarus Philip, La Vecchia Carlo, Koifman Sergio, Kelsey Karl, Herrero Rolando, Haynes Richard B., Franceschi Silvia, Fernandez Leticia, Fabianova Eleonora, Daudt Alexander W., Dal Maso Luigino, Curado Maria Paula, Cadoni Gabriella, Chen Chu, Castellsague Xavier, Boccia Stefania, Benhamou Simone, Ferro Gilles, Berthiller Julien, Brennan Paul, Møller Henrik, Hashibe Mia
ISSN
1464-3685[electronic]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
39
Number
1
Pages
182-196
Language
english
Abstract
BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. METHODS: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. RESULTS: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after >/=20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after >/=20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. CONCLUSIONS: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.
Pubmed
Web of science
Open Access
Yes
Create date
30/12/2009 11:24
Last modification date
25/09/2019 6:08
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