The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells

Details

Serval ID
serval:BIB_35F0AFCBA261
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells
Journal
Journal of Immunology
Author(s)
Speiser  D. E., Colonna  M., Ayyoub  M., Cella  M., Pittet  M. J., Batard  P., Valmori  D., Guillaume  P., Lienard  D., Cerottini  J. C., Romero  P.
ISSN
0022-1767 (Print)
Publication state
Published
Issued date
12/2001
Volume
167
Number
11
Pages
6165-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Abstract
The membrane receptor 2B4 is a CD2 family member that is involved in lymphocyte activation. A fraction of human CD8+ alphabeta T cells up-regulate 2B4 in vivo, and here we demonstrate that this correlates with the acquisition of effector cell properties such as granzyme B and perforin expression, rapid IFN-gamma production, and down-regulation of the lymph node homing chemokine receptor CCR7. In PBLs from healthy donors, cytomegalovirus-specific effector T cells were 2B4 positive, whereas naive melanoma Ag (Melan-A/melanoma Ag recognized by T cells-1)-specific T cells were 2B4 negative. In melanoma patients, Melan-A-specific T cells up-regulated 2B4 in parallel with in vivo differentiation. This occurred in PBLs after vaccination with Melan-A peptides and in tumor-infiltrated lymph nodes, likely through disease-associated activation of Melan-A-specific T cells. Thus, 2B4 expression correlates with CD8+ T cell differentiation in vivo.
Keywords
*Antigens, CD Antigens, Neoplasm CD8-Positive T-Lymphocytes/cytology/enzymology/*immunology/*metabolism Cancer Vaccines/immunology/therapeutic use Cell Differentiation/immunology Cell Separation Epitopes, T-Lymphocyte/analysis Granzymes Humans Interferon Type II/biosynthesis Interphase/immunology Lymphocyte Activation Melanoma/immunology/therapy Membrane Glycoproteins/*biosynthesis Neoplasm Proteins/immunology/therapeutic use Pore Forming Cytotoxic Proteins Receptors, Antigen, T-Cell, alpha-beta/*immunology Receptors, Immunologic/*biosynthesis Serine Endopeptidases/biosynthesis T-Lymphocyte Subsets/cytology/enzymology/*immunology/*metabolism Up-Regulation/immunology
Pubmed
Web of science
Create date
28/01/2008 11:13
Last modification date
20/08/2019 13:23
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