The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells
Details
Serval ID
serval:BIB_35F0AFCBA261
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells
Journal
Journal of Immunology
ISSN
0022-1767 (Print)
Publication state
Published
Issued date
12/2001
Volume
167
Number
11
Pages
6165-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Abstract
The membrane receptor 2B4 is a CD2 family member that is involved in lymphocyte activation. A fraction of human CD8+ alphabeta T cells up-regulate 2B4 in vivo, and here we demonstrate that this correlates with the acquisition of effector cell properties such as granzyme B and perforin expression, rapid IFN-gamma production, and down-regulation of the lymph node homing chemokine receptor CCR7. In PBLs from healthy donors, cytomegalovirus-specific effector T cells were 2B4 positive, whereas naive melanoma Ag (Melan-A/melanoma Ag recognized by T cells-1)-specific T cells were 2B4 negative. In melanoma patients, Melan-A-specific T cells up-regulated 2B4 in parallel with in vivo differentiation. This occurred in PBLs after vaccination with Melan-A peptides and in tumor-infiltrated lymph nodes, likely through disease-associated activation of Melan-A-specific T cells. Thus, 2B4 expression correlates with CD8+ T cell differentiation in vivo.
Keywords
*Antigens, CD
Antigens, Neoplasm
CD8-Positive T-Lymphocytes/cytology/enzymology/*immunology/*metabolism
Cancer Vaccines/immunology/therapeutic use
Cell Differentiation/immunology
Cell Separation
Epitopes, T-Lymphocyte/analysis
Granzymes
Humans
Interferon Type II/biosynthesis
Interphase/immunology
Lymphocyte Activation
Melanoma/immunology/therapy
Membrane Glycoproteins/*biosynthesis
Neoplasm Proteins/immunology/therapeutic use
Pore Forming Cytotoxic Proteins
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Receptors, Immunologic/*biosynthesis
Serine Endopeptidases/biosynthesis
T-Lymphocyte Subsets/cytology/enzymology/*immunology/*metabolism
Up-Regulation/immunology
Pubmed
Web of science
Create date
28/01/2008 12:13
Last modification date
20/08/2019 14:23