Increased FGF21 plasma levels in humans with sepsis and SIRS.

Details

Serval ID
serval:BIB_35E007E184CA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Increased FGF21 plasma levels in humans with sepsis and SIRS.
Journal
Endocrine Connections
Author(s)
Gariani K., Drifte G., Dunn-Siegrist I., Pugin J., Jornayvaz F.R.
ISSN
2049-3614 (Electronic)
ISSN-L
2049-3614
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
2
Number
3
Pages
146-153
Language
english
Abstract
Fibroblast growth factor 21 (FGF21) is a key regulator in glucose and lipid metabolism and its plasma levels have been shown to be increased not only in humans in different situations such as type 2 diabetes, obesity, and nonalcoholic fatty liver disease but also in animal models of sepsis and pancreatitis. FGF21 is considered as a pharmacological candidate in conditions associated with insulin resistance. The aim of this study was to compare FGF21 plasma levels in patients with sepsis, in patients with systemic inflammatory response syndrome (SIRS), and in healthy controls. We measured FGF21 plasma concentrations in 22 patients with established sepsis, in 11 with SIRS, and in 12 healthy volunteers. Here, we show that FGF21 levels were significantly higher in plasma obtained from patients with sepsis and SIRS in comparison with healthy controls. Also, FGF21 levels were significantly higher in patients with sepsis than in those with noninfectious SIRS. FGF21 plasma levels measured at study entry correlated positively with the APACHE II score, but not with procalcitonin levels, nor with C-reactive protein, classical markers of sepsis. Plasma concentrations of FGF21 peaked near the onset of shock and rapidly decreased with clinical improvement. Taken together, these results indicate that circulating levels of FGF21 are increased in patients presenting with sepsis and SIRS, and suggest a role for FGF21 in inflammation. Further studies are needed to explore the potential role of FGF21 in sepsis as a potential therapeutic target.
Pubmed
Open Access
Yes
Create date
10/09/2015 12:02
Last modification date
20/08/2019 13:23
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