Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_35DBB703320E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus.
Journal
Frontiers in immunology
Author(s)
Nehring J., Schirmbeck L.A., Friebus-Kardash J., Dubler D., Huynh-Do U., Chizzolini C., Ribi C., Trendelenburg M.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Pages
2090
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Objectives: Autoantibodies and aberrant immune complexes are pathological hallmarks of systemic lupus erythematosus (SLE). This study aimed to determine the occurrence of IgG autoantibodies against human serum albumin (anti-HSA IgG) and their potential association with antibodies against bovine serum albumin (anti-BSA IgG) in patients with SLE. Methods: Sera of 180 SLE patients included to the Swiss SLE Cohort Study and 188 age- and sex-matched healthy controls were evaluated. Levels of anti-HSA IgG and anti-BSA IgG were quantified by ELISA. Selected samples were further characterized using serum fractions obtained by fast liquid chromatography (FPLC). Results: SLE patients had increased levels of anti-HSA IgG (p = 0.002) but similar levels of anti-BSA IgG compared to matched healthy controls. Anti-HSA IgG levels correlated with the SLE Disease Activity Index (SLEDAI), which was more pronounced in patients with an physician's global assessment (PGA) of ≥ 1 (r = 0.309, p = 0.0066). Anti-HSA IgG was partially complexed with serum albumin but also occurred as monomeric autoantibodies in highly positive SLE patients. A positive correlation between anti-HSA IgG and anti-BSA IgG was found that was stronger in SLE patients than in healthy controls (r = 0.3172, p < 0.001 vs. r = 0.2122, p < 0.0035). Binding of anti-BSA IgG was inhibited partially in the presence of HSA in samples with double positivity for anti-HSA and anti-BSA (median inhibition 47.9%, range 0.9-100%) and vice versa. Conclusion: In SLE patients there is an increased prevalence of anti-HSA IgG antibodies that are associated with SLE disease activity.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Autoantibodies/blood, Autoantibodies/immunology, Cohort Studies, Female, Humans, Immunoglobulin G/blood, Immunoglobulin G/immunology, Lupus Erythematosus, Systemic/blood, Lupus Erythematosus, Systemic/immunology, Male, Middle Aged, Serum Albumin, Human/immunology, Serum Albumin, Human/metabolism, antibodies, human serum albumin, multicenter study, patients, systemic lupus erythematosus
Pubmed
Web of science
Open Access
Yes
Create date
15/10/2018 16:27
Last modification date
28/09/2019 5:08
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