Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients.

Details

Serval ID
serval:BIB_35BF366742E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients.
Journal
Cancers
Author(s)
Al-Ibraheem A., Al-Rasheed U., Mashhadani N., Abdlkadir A.S., Al-Adhami D.A., Ruzzeh S., Istatieh F., Mansour A., Hamdan B., Kheetan R., Al-Shatti M., Mohamad I., Juweid M.E., Abu Sheikha A., Al-Rabi K., Sykiotis G.P., Kreissl M.C., Ismael T., Sultan I., Abdel-Razeq H.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
15/08/2023
Peer-reviewed
Oui
Volume
15
Number
16
Pages
4102
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
DTC accounts for the majority of endocrine tumors. While the incidence of thyroid cancer has been increasing globally over the past few decades, papillary thyroid carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to assess the 5- and 10-year overall survival (OS) and progression-free survival (PFS) of 528 Arabic patients diagnosed with primary DTC from 1998 to 2021. Additionally, the study aimed to analyze the impact of various factors on both OS and PFS. An univariable survival analysis was conducted using Kaplan-Meier curves. The 5- and 10-year OS for patients with DTC have exceeded 95%. Additionally, PFS showed very good rates (ranging between 96.5 and 85% at 5 and 10 years, respectively). Age, male gender, risk of recurrence, and distant metastasis were identified as the main negative prognostic factors for both OS and PFS, while RAI treatment was found to be a significant factor in improving OS. Moreover, adherence to the King Hussein Cancer Center's (KHCC) CPG demonstrated significant improvement in PFS. These findings highlight common prognostic factors and favorable outcomes in Arabic patients with DTC treated at a tertiary cancer center using standard of care approaches.
Keywords
Khcc, differentiated thyroid cancer, papillary thyroid cancer, prognostic factors, radioactive iodine, thyroid cancer, KHCC
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2023 14:05
Last modification date
19/12/2023 7:15
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