Pathogenicity Genomic Island-Associated CrpP-Like Fluoroquinolone-Modifying Enzymes among Pseudomonas aeruginosa Clinical Isolates in Europe.

Details

Serval ID
serval:BIB_35BEFDFE832A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pathogenicity Genomic Island-Associated CrpP-Like Fluoroquinolone-Modifying Enzymes among Pseudomonas aeruginosa Clinical Isolates in Europe.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Ortiz de la Rosa J.M., Nordmann P., Poirel L.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
23/06/2020
Peer-reviewed
Oui
Volume
64
Number
7
Pages
e00489-20
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Many transferable quinolone resistance mechanisms have been identified in Gram-negative bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP was recently identified in Pseudomonas aeruginosa isolates. We analyzed a collection of 100 clonally unrelated and multidrug-resistant P. aeruginosa clinical isolates, among which 46 were positive for crpP-like genes, encoding five CrpP variants conferring variable levels of reduced susceptibility to fluoroquinolones. These crpP-like genes were chromosomally located as part of pathogenicity genomic islands.
Keywords
Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Drug Resistance, Bacterial, Europe, Fluoroquinolones/pharmacology, Genomic Islands/genetics, Microbial Sensitivity Tests, Pseudomonas aeruginosa/genetics, Virulence, CrpP, Pseudomonas aeruginosa, ciprofloxacin, fluoroquinolones
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2020 15:15
Last modification date
23/03/2024 8:22
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