Two years' effectiveness of intravenous pamidronate (APD) versus oral fluoride for osteoporosis occurring in the postmenopause.

Details

Serval ID
serval:BIB_35BA4830909E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Two years' effectiveness of intravenous pamidronate (APD) versus oral fluoride for osteoporosis occurring in the postmenopause.
Journal
Osteoporosis international
Author(s)
Thiébaud D., Burckhardt P., Melchior J., Eckert P., Jacquet A.F., Schnyder P., Gobelet C.
ISSN
0937-941X (Print)
ISSN-L
0937-941X
Publication state
Published
Issued date
03/1994
Peer-reviewed
Oui
Volume
4
Number
2
Pages
76-83
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Bisphosphonates seem to be effective as antiresorptive agents in the prevention and treatment of osteoporosis. However, the optimal dose and route of administration as well as the specific effects on cortical or trabecular bone have not been clarified. To compare pamidronate (APD) with fluoride (F) in the therapy of postmenopausal osteoporosis, 32 osteoporotic women were treated for 2 years either with APD (30 mg as a single intravenous infusion over 1 h every 3 months, n = 16, mean age 65 years) or with fluoride orally (20-30 mg F/day, n = 16, mean age 67 years) in an open study. Both groups received 1 g calcium and 1000 U vitamin D per day, but no estrogens or other drugs acting on bone. Both groups showed the same initial mean number of fractures per patient (2.8 and 2.7). Bone densitometry was performed every 6 months at three sites: lumbar spine and hip with dual-energy X-ray absorptiometry (BMD), distal forearm with single photon absorptiometry and lumbar spine with quantitative computed tomography. Biochemical assessment was performed in blood and urine every 3 months. Lumbar BMD (g/cm2, mean +/- SEM) increased from 0.632 (+/- 0.030) at time 0 to 0.696 (+/- 0.028) at 24 months in the APD group (p < 0.001), and from 0.684 (+/- 0.025) to 0.769 (+/- 0.028) in the fluoride group (p < 0.001). Femoral neck BMD increased significantly from 0.558 (+/- 0.025) to 0.585 (+/- 0.025) (p < 0.01) in the APD group, whereas it did not change in the fluoride group.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Administration, Oral, Adult, Aged, Aged, 80 and over, Bone Density/drug effects, Bone Density/physiology, Diphosphonates/administration & dosage, Diphosphonates/adverse effects, Female, Femur Neck/physiopathology, Fluorides/administration & dosage, Fluorides/adverse effects, Follow-Up Studies, Humans, Infusions, Intravenous, Lumbar Vertebrae/physiopathology, Middle Aged, Osteoporosis, Postmenopausal/drug therapy, Osteoporosis, Postmenopausal/physiopathology, Radius/physiopathology, Time Factors, Treatment Outcome
Pubmed
Web of science
Create date
12/06/2018 14:03
Last modification date
20/08/2019 13:23
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