Profound impact of uncomplicated pregnancy on diastolic, but not systolic pulse contour of aortic pressure
Details
Serval ID
serval:BIB_35B406A6C551
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Profound impact of uncomplicated pregnancy on diastolic, but not systolic pulse contour of aortic pressure
Journal
Journal of Hypertension
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
08/2006
Volume
24
Number
8
Pages
1641-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
OBJECTIVE: To evaluate the impact of uncomplicated pregnancy on the pulse contour of central aortic pressure. METHODS: A total of 66 women with singleton pregnancy were grouped according to pregnancy duration: first trimester (T1, n = 22), second trimester (T2, n = 20), and third trimester (T3, n = 24). Non-pregnant healthy women, who took combined oral contraception, were included as controls (C, n = 21). The pulse contour of aortic pressure was obtained with radial applanation tonometry, using a commercial device (SphygmoCor). The influence of reflected waves on the contour was evaluated not only in systole, as usual with pulse contour analysis (systolic augmentation), but also in diastole (diastolic augmentation). RESULTS: Throughout pregnancy, central systolic and diastolic blood pressure remained unchanged and comparable to values in the non-pregnant state. Systolic augmentation amounted to 8.1 +/- 7.5% of pulse pressure in the control group (mean +/- SD), and there was no statistically significant deviation from this value at any stage of pregnancy (T1, 4.6 +/- 11.4%; T2, 5.0 +/- 9.3%; T3, 4.7 +/- 8.1%). In contrast, the amplitude of the diastolic augmentation wave progressively declined with advancing pregnancy (C, 6.5 +/- 2.4%; T1, 5.2 +/- 3.1%; T2, 3.8 +/- 2.6%; P = 0.002 versus C, T3, 2.3 +/- 2.0%; P < 0.0001 versus C and P = 0.0004 versus T1). CONCLUSION: The systolic shape of the central aortic pressure contour is left unaltered by pregnancy, implying a finely tuned adaptation of the cardiovascular system to the increased demand for blood flow at all stages of the gravid state. In contrast, the amplitude of reflection waves reaching the aortic root in diastole progressively decreases with advancing pregnancy.
Keywords
Adult
Analysis of Variance
Aorta/*physiology
Blood Pressure/*physiology
Brachial Artery/physiology
Cross-Sectional Studies
Diastole/physiology
Female
Forearm/blood supply
Heart Rate/physiology
Humans
Manometry
Pregnancy/*physiology
Pregnancy Trimesters
Reference Values
Stroke Volume/physiology
Systole/physiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:38
Last modification date
20/08/2019 14:23