Interleukin (IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12.

Details

Serval ID
serval:BIB_358418B280FC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Interleukin (IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12.
Journal
Journal of Infectious Diseases
Author(s)
Bourreau E., Prévot G., Pradinaud R., Launois P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
2001
Volume
183
Number
6
Pages
953-959
Language
english
Abstract
Semiquantitative reverse transcription-polymerase chain reaction analysis of leishmania lesion cytokine profile showed a Th2 cytokine expression pattern, as reflected by interleukin (IL)-4 and IL-13 mRNA expression. There was a predominance of IL-13 in most lesions from patients with American localized cutaneous leishmaniasis caused by Leishmania guyanensis. IL-13 production by peripheral blood mononuclear cells in response to specific leishmania antigens was confirmed in these patients. The absence of the second chain of the IL-12 receptor (IL-12Rbeta2) mRNA expression in lesions and the presence of specific IgE and IgG4 in some serum samples demonstrated the functional role of these Th2 cytokines. IL-13, unlike IL-4, rendered specific T cells unresponsive to IL-12 by inhibiting the expression of the IL-12Rbeta2 chain. These data establish the crucial role of IL-13 in human cutaneous leishmaniasis.
Keywords
Animals, Antibodies, Protozoan/biosynthesis, Antigens, Protozoan/immunology, CD4-Positive T-Lymphocytes/immunology, Cells, Cultured, Cytokines/biosynthesis, Cytokines/genetics, Humans, Immune Tolerance, Immunoglobulin E/biosynthesis, Immunoglobulin G/biosynthesis, Interleukin-12/pharmacology, Interleukin-13/biosynthesis, Interleukin-13/genetics, Interleukin-4/biosynthesis, Interleukin-4/genetics, Leishmania guyanensis/immunology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/pathology, Leukocytes, Mononuclear/drug effects, Leukocytes, Mononuclear/immunology, Lymphocyte Activation, Receptors, Interleukin/biosynthesis, Receptors, Interleukin/genetics, Receptors, Interleukin-12, Th2 Cells/immunology, Transcriptional Activation
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:06
Last modification date
20/08/2019 13:23
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