Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome.
Details
Serval ID
serval:BIB_355592F366CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome.
Journal
Frontiers in medicine
Working group(s)
Spanish Sleep Network
Contributor(s)
Abad L., Munϸoz A., Zamora E., Vicente I., Ingleìs S., Egea C., Marcos J., Fernaìndez A., Cabriada-Nuño V., Castro S., Serrano L., Floreìs M., Mas A., Arboneìs M., Ortega S., Martiìn A., Romaìn-Saìnchez J.M., Valiente-Diaz M.I., Viejo-Ayuso M.E., Rodriìguez-Garciìa C., Vigil L., Ramiìrez E., Pinϸar M., Martiìnez E., Barriuso B., Corral J., Goìmez de Terreros Caro F.J., Barceloì A., Gimeìnez P., Fortuna A.M., Penñacoba P., Martiìnez-Garciìa A.J., Garciìa-Castillo S., Navas L., Garmendia O., Sancho J., Perelloì S., Rubinoìs G., Gallego R.
ISSN
2296-858X (Print)
ISSN-L
2296-858X
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
9
Pages
870906
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acute coronary syndrome (ACS). We aim to identify respiratory polygraphy (RP) patterns that contribute to identifying the risk of recurrent cardiovascular events in patients with ACS.
Post hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO <sub>2</sub> ), average duration of events and percentage of time with SaO <sub>2</sub> < 90%. An independent HypnoLaus population-based cohort was used to validate the RP components.
From the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO <sub>2</sub> and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO <sub>2</sub> and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events.
A RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS.
Post hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO <sub>2</sub> ), average duration of events and percentage of time with SaO <sub>2</sub> < 90%. An independent HypnoLaus population-based cohort was used to validate the RP components.
From the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO <sub>2</sub> and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO <sub>2</sub> and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events.
A RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS.
Keywords
acute coronary syndrome, cardiovascular disease, obstructive sleep apnea, precision medicine, respiratory polygraphy
Pubmed
Web of science
Open Access
Yes
Create date
26/07/2022 12:58
Last modification date
07/03/2023 6:48
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