Evolution of repeated sequence arrays in the D-loop region of bat mitochondrial DNA.

Details

Serval ID
serval:BIB_354EBEE95907
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evolution of repeated sequence arrays in the D-loop region of bat mitochondrial DNA.
Journal
Genetics
Author(s)
Wilkinson G.S., Mayer F., Kerth G., Petri B.
ISSN
0016-6731
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
146
Number
3
Pages
1035-1048
Language
english
Abstract
Analysis of mitochondrial DNA control region sequences from 41 species of bats representing 11 families revealed that repeated sequence arrays near the tRNA-Pro gene are present in all vespertilionine bats. Across 18 species tandem repeats varied in size from 78 to 85 bp and contained two to nine repeats. Heteroplasmy ranged from 15% to 63%. Fewer repeats among heteroplasmic than homoplasmic individuals in a species with up to nine repeats indicates selection may act against long arrays. A lower limit of two repeats and more repeats among heteroplasmic than homoplasmic individuals in two species with few repeats suggests length mutations are biased. Significant regressions of heteroplasmy, theta and pi, on repeat number further suggest that repeat duplication rate increases with repeat number. Comparison of vespertilionine bat consensus repeats to mammal control region sequences revealed that tandem repeats of similar size, sequence and number also occur in shrews, cats and bighorn sheep. The presence of two conserved protein-binding sequences in all repeat units indicates that convergent evolution has occurred by duplication of functional units. We speculate that D-loop region tandem repeats may provide signal redundancy and a primitive repair mechanism in the event of somatic mutations to these binding sites.
Keywords
Animals, Base Sequence, Cats, Chiroptera/genetics, DNA, Mitochondrial, Evolution, Molecular, Humans, Mammals/genetics, Molecular Sequence Data, Mutation, Repetitive Sequences, Nucleic Acid, Selection (Genetics), Sequence Homology, Nucleic Acid
Pubmed
Web of science
Create date
19/11/2007 10:08
Last modification date
20/08/2019 13:22
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