Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.

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Version: Final published version
Serval ID
serval:BIB_35434F662256
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.
Journal
Scientific reports
Author(s)
Richard C., Courbon G., Laroche N., Prades J.M., Vico L., Malaval L.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
06/07/2017
Peer-reviewed
Oui
Volume
7
Number
1
Pages
4825
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.
Keywords
Abortion, Spontaneous, Calcification, Physiologic/physiology, Ear, Inner/anatomy & histology, Ear, Inner/diagnostic imaging, Ear, Inner/growth & development, Ear, Middle/anatomy & histology, Ear, Middle/diagnostic imaging, Ear, Middle/growth & development, Female, Fetal Death, Fetal Development/physiology, Fetus/anatomy & histology, Fetus/diagnostic imaging, Gestational Age, Hearing/physiology, Humans, Osteogenesis/physiology, Postural Balance/physiology, Pregnancy, X-Ray Microtomography
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2017 15:19
Last modification date
20/08/2019 14:22
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