Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy.

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Serval ID
serval:BIB_3536D034BF52
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy.
Journal
Channels
Author(s)
Ito N., Ruegg U.T., Kudo A., Miyagoe-Suzuki Y., Takeda S.
ISSN
1933-6969 (Electronic)
ISSN-L
1933-6950
Publication state
Published
Issued date
2013
Volume
7
Number
3
Pages
221-224
Language
english
Notes
Publication types: Comment ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Mechanical load-induced intracellular signaling events are important for subsequent skeletal muscle hypertrophy. We previously showed that load-induced activation of the cation channel TRPV1 caused an increase in intracellular calcium concentrations ([Ca ( 2+) ]i) and that this activated mammalian target of rapamycin (mTOR) and promoted muscle hypertrophy. However, the link between mechanical load-induced intracellular signaling events, and the TRPV1-mediated increases in [Ca ( 2+) ]i are not fully understood. Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3β. Furthermore, the TRPV1-induced phosphorylation patterns resembled those induced by mechanical load. Our results continue to highlight the importance of TRPV1-mediated calcium signaling in load-induced intracellular signaling pathways.
Pubmed
Web of science
Create date
13/09/2013 16:32
Last modification date
20/08/2019 13:22
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