Antihypertensive and lipid lowering treatment in stroke prevention: current state and future.

Details

Serval ID
serval:BIB_35343
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antihypertensive and lipid lowering treatment in stroke prevention: current state and future.
Journal
Acta Neurologica Belgica
Author(s)
Piechowski-Jóźwiak B., Bogousslavsky J.
ISSN
0300-9009
Publication state
Published
Issued date
2005
Volume
105
Number
2
Pages
57-61
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
Diabetes mellitus, arterial hypertension, smoking are major stroke risk factors. The role of hypercholesterolemia in stroke has not been established yet. In patients with type 2 diabetes mellitus there is evidence that intensive glucose lowering therapy diminishes the risk of microvascular complications. In all patients with stroke or transient ischemic attack (TIA), blood pressure should be lowered irrespectively of the baseline level with either diuretics, angiotensin converting enzyme (ACE) inhibitors, beta-blockers, or calcium antagonists. The role of angiotensin II (AT2) receptor blockers has not been established so far. In general terms a global approach to management of patients with vascular risk factors should be developed. An extended follow-up of randomised trials on preventive therapy should be completed. Controlled trials comparing angiotensin receptor blockers with ACE inhibitors should be started. Further research may focus on the new lipid lowering agents, and on the comparison of single lipid lowering agent vs. combinations in stroke prevention. These efforts should help in finding the best vasoprotective strategy in stroke prevention.
Keywords
Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Antihypertensive Agents/pharmacology, Antihypertensive Agents/therapeutic use, Antilipemic Agents/pharmacology, Antilipemic Agents/therapeutic use, Clinical Trials as Topic/standards, Humans, Hyperlipidemias/complications, Hyperlipidemias/drug therapy, Hypertension/complications, Hypertension/drug therapy, Receptors, Angiotensin/antagonists & inhibitors, Receptors, Angiotensin/metabolism, Risk Factors, Stroke/etiology, Stroke/physiopathology
Pubmed
Web of science
Create date
19/11/2007 12:33
Last modification date
20/08/2019 13:22
Usage data